hDLL3/MC-38
CBPG0117
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| I. Background | |||||||||||
| DLL3 基因別名 SCDO1，其編碼的蛋白 DLL3 是一種跨膜蛋白，是 Notch 受體配體 Delta/Serrate/lag2（DSL）組的成員，在胚層的分離中，影響著體細(xì)胞邊界的形成。 DLL3 基因突變會(huì)導(dǎo)致嚴(yán)重的體節(jié)發(fā)生異常和脊椎肋骨發(fā)育不全。DLL3 是一種高度腫瘤選 擇性的細(xì)胞表面靶點(diǎn)，在正常肺癌組織及癌旁組織中不表達(dá)。DLL3 在多種腫瘤中表達(dá)上 調(diào)，在小細(xì)胞肺癌、乳腺癌、垂體瘤、急性髓系白血病中有促癌作用，但在肝癌 、神經(jīng)膠 質(zhì)瘤和惡性膠質(zhì)瘤中卻發(fā)揮了抑癌作用。 | |||||||||||
| II. Introduction | |||||||||||
| Host Cell: | MC-38 | ||||||||||
| Expressed gene: | DLL3 | ||||||||||
| Stability: | 32 passages | ||||||||||
| Freeze Medium: | 90% FBS+10% DMSO | ||||||||||
| Culture Medium: | DMEM+10%FBS+5μg/ml Puromycin | ||||||||||
| Mycoplasma Testing: | Negative | ||||||||||
| Storage: | Liquid nitrogen | ||||||||||
| III. Description of Host Cell Line | |||||||||||
| Organism: | Mouse | ||||||||||
| Tissue: | Colon | ||||||||||
| Morphology: | Epitheloid cell | ||||||||||
| Growth Properties: | Adherent | ||||||||||
| IV. Representative Data
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| V. In VIVO Data | |||||||||||
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1. Weight Change
Figure 2. hDLL3/MC38 Mean Body Weight ± SEM.
2. Tumor Size
Figure 3. hDLL3/MC38 Mean Tumor Volume ± SEM .
NOTE：The above data was provided by Cobioer (cell data) and Truway Bio (in vivo data model).
